TOCOLYSIS WITH INDOMETHACIN IS ASSOCIATED WITH PATENT DUCTUS ARTERIOSUS (PDA) REFRACTORY TO THERAPY. † 1308

Indomethacin tocolysis increases postnatal patent ductus arteriosus severity.

UNLABELLED Postnatally, therapeutic indomethacin administration is usually effective in mediating patent ductus arteriosus (PDA) constriction in premature infants. There are infants, however, who remain resistant to indomethacin and require more aggressive surgical intervention to facilitate ductal closure. Indomethacin tocolysis has been reported to increase the incidence of persistent PDA in ...

ductus arteriosus with indomethacin

The effect of indomethacin treatment of patent ductus arteriosus (PDA) on blood pressure was studied in 24 preterm infants. PDA was diagnosed clinically and confirmed by echocardiography; the effect of treatment was monitored echocardiographically. Hourly intra-arterial recordings of systolic, diastolic, and mean blood pressure were averaged for the 48 hours before the first dose of indomethaci...

Hearing Loss Associated with Patent Ductus Arteriosus

The Ductus Arteriosus is a cardinal for foetal vascular circulation which closes immediately after birth and consistently within 48 hours of birth. It is considered abnormal if it remains open till 3 months of age [2]. The clinical sign and symptoms of PDA depend primarily on the size of shunt and the basic cardiovascular condition of the patient. The prevalence of PDA accounts 5 to 10% of all ...

Ibuprofen vs. Indomethacin in the Closure of the Patent Ductus Arteriosus (PDA)

Intravenous Paracetamol and Patent Ductus Arteriosus Closure

Background: Standard medical treatments for patent ductus arteriosus (PDA) closure are, including indomethacin/ibuprofen and surgical ligation. Nowadays, a new strategy to close PDA is the use of paracetamol. The present study aimed to describe the use of intravenous (IV) paracetamol for PDA closure in neonates who present a contraindication to ibuprofen or ibuprofen failure with no possibility...